This relatively recent field has becoming depositary of big hopes after the discovery that larvae of some Lepidoptera and Coleoptera could degrade sturdy synthetic polymers as PE and PS.
Our lab discovered the fastest of all, the larvae of lepidopteran Galleria mellonella, also called wax worm.
Our main player is the wax worm, the fastest one’ the centre of our attention since the start (Bombelli et al., 2017). Since this first report about the capacity of the wax worm to oxidize, and therefore degrade, PE, many other reports confirmed and extended this capacity to PS. Adding to it the ability to oxidize PP as well (unpublished observations), this makes the wax worm the most suitable candidate in our quest for resilient plastics’ degraders.
The research projects the lab is centred on starts from here.
2023 Federica Bertocchini, Clemente F. Arias. Why have we not yet solved the challenge of plastic degradation by biological means? 2023. PLoS Biology, Mar 7;21(3) doi: 10.1371/journal.pbio.3001979
2023 Serrano-Antón, B., Rodríguez-Ventura, F., Colomer-Vidal, P., Aiese Cigliano, R., Arias, C- F. and Bertocchini, F. The virtualome: a computational framework to evaluate microbiome analyses. 2023. PLoS One, Feb 8;18(2), doi: 10.1371/journal.pone.0280391
2022 A. Sanluis-Verdes, P. Colomer-Vidal, F. Rodriguez-Ventura, M. Bello-Villarino, M. Spinola-Amilibia, E. Ruiz-Lopez, R. Illanes-Vicioso, P. Castroviejo, R. Aiese Cigliano, M. Montoya, P. Falabella, C. Pesquera, L. Gonzalez-Legarreta, E. Arias-Palomo, M. Solà, T. Torroba, C. F. Arias, Bertocchini, F. Wax wormsaliva and the enzymes therein are the key to polyethylene degradation by Galleria mellonella. Nat Commun, 2022 Oct 4;13(1):5568. doi: 10.1038/s41467-022-33127-w
https://www.nature.com/articles/s41467-022-33127-w
2017 Arias, C.F*, Herrero, M.A., Stern, C.D. and Bertocchini, F.* (2017) A molecular mechanism of symmetry breaking in the early chick embryo, Scientific Reports November 17;7(1): 15883-8. (*corresponding authors)
2017 Bombelli P, Howe C.J.* and Bertocchini F.* (2017) Polyethylene bio-degradation by caterpillars of the wax moth Galleria mellonella. Current Biology, 2017 Apr 24; 27(8):R292-R293 (*corresponding authors)
2017 Matthew J. Stower* and Federica Bertocchini*, The Evolution of Amniote Gastrulation: the blastopore-primitive streak transition. Wiley Interdisciplinary Reviews: Developmental Biology, Volume 2(2). (*corresponding authors)
2016 Bertocchini F.* and Chuva de Sousa Lopes, S.M.*, Germline development in amniotes: A paradigm shift in primordial germ cell specification Invited Review: Paradigm and Hypothesis, Bioessays, Aug; 38(8):791-800, 2016 (*corresponding authors)
2015 Stower, M.J., Diaz, R.E., Carrera-Fernandez, L., White Crother, M., Crother, B., Marco, A. Trainor, P.A. Srinivas, S. and Bertocchini F.* Bi-modal strategy of gastrulation in reptiles, Developmental Dynamics, special edition on Evolution, June 09 2015 (9), 1144-1157. (*corresponding author)
2012 Bertocchini F. * and Stern, C.D.* “GATA2 provides an early anterior bias and uncovers a global positioning system for polarity in the amniote embryo”Development 139, 4232-4238 (*corresponding author)
2007 Voiculescu, O., Bertocchini, F., Keller, R. and Stern, C.D. “The amniote primitive streak is defined by epithelial cell intercalation before gastrulation”, Nature 449, 1049-1052
2004 Bertocchini, F., I. Skromne, L. Wolpert and Stern, C.D. “Determination of embryonic polarity in a regulative system: evidence for endogenous inhibitors acting sequentially during primitive streak formation in the chick embryo” Development 131, 3381-3390
2002 Bertocchini, F. and Stern, C.D. “The hypoblast of the chick embryo positions the primitive streak by antagonizing Nodal signaling”, Developmental Cell 3, 735–744
After obtaining her PhD at the DIBIT, S. Raphael Hospital, Milan, she worked on early development of vertebrates, training in the USA (Columbia University, New York, NY) and the UK (University College London, London, UK). She started to work on insects and their capacity to degrade sturdy polymers (Bombelli et al., 2017) and is currently carrying on this line of research at plasticentropy S.L
C.F.A. has a solid background both in Mathematics and Biology. In particular, C.F.A. holds a Ph.D. degree in Biology and a master’s degree in Mathematics, with 20+ years of experience in the field of mathematical modeling of biological processes at all scales, from biochemistry and cell biology to ecology. His current research lines lie at the intersection between bioinformatics, immunology, and mathematical modeling of metabolic networks, and mainly focus on the understanding of how homeostasis mechanisms operate in the organism under normal circumstances.
Spanish Research Council (CSIC), Spain, 09/2019-08/2022
Ministry of Science and Innovation, Government of Spain,National Plan I+D+I for not oriented research Grant number: BFU2010-19656 (2010)
Fundacion Ramon Areces,XIV Concurso Ciencias de la Vida y de la Materia (2012)
Royal Society International exchange grant with Dr. S. Srinivas, Oxford University, Oxford, UK (07/2013-06/2014)